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VIAGRA [Sildenafil citrate] An Overview
VIAGRA [Sildenafil citrate] is the only approved and effective oral agent for the treatment of erectile dysfunction. Before that a few lines on erectile dysfunction. Erectile dysfunction [Impotence] is a condition in which erection the penis cannot be achieved during sexual intercourse/masturbation. There are many causes for erectile dysfunction. The most common cause of being increasing age. Other conditions can be: - Diabetes Mellitus - Hypertension - Heart Disease - Atherosclerosis - Lower spinal cord injury - Cancer prostate - Psychogenic - Stress Erection is achieved when there is increased blood flow to penis and hence the main organic cause is disturbance of blood flow to and from the penis. Coming back to VIAGRA [Sildenafil citrate], Viagra is a selective and potent inhibitor of cyclic guanosine monophosphate [cGMP] specific phosphodiesterase type 5 inhibitor [PDE5] which is the predominant phosphodiesterase isoform found in the penis. It is administered in doses of 25, 50 and 100 mg, and enhances erection after sexual stimulation. The onset of action is around 60-90 mins. Sildenafil (compound UK-92,480) was synthesized by a group of chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension and angina pectoris. The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. VIAGRA [Sildenafil citrate] was approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction Reduced initial doses should be considered for patients, who are elderly, have renal insufficiency, or are taking medications that inhibit the CYP3A4 metabolic pathway in the liver [e.g., erythromycin, cimetidine, ketoconazole] as they may increase the serum concentration of sildenafil. The drug does not affect ejaculation, orgasm or sexual drive. When sexual stimulation causes local release of NO, inhibition of PDE5 by VIAGRA [Sildenafil citrate] causes increased levels of cGMP in the corpus cavernosum of the penis resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Side Effects: ?? Headaches ?? Facial flushing ?? ringing in ears, or sudden hearing loss ?? Dyspepsia ?? Nasal congestion. ?? Abnormal vision [blue halo effect] ?? Diarrhea ?? Dizziness ?? Rashes Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss:- Special precautions: In patients with ?? Bleeding disorders such as hemophilia ?? Liver disorder ?? Kidney disorder ?? Active peptic ulcerations and ?? Anatomical deformation of the penis, such as peyronie's disease. ?? Retinitis pigmentosa Contraindications: VIAGRA [Sildenafil citrate], is contraindicated in men receiving nitrate therapy for cardiovascular disease, including agents delivered by oral, sublingual, trans-nasal or topical routes. These agents can potentates its hypotensive effect and may result in profound shock. Viagra should be avoided in patients with congestive heart failure and cardiomyopathy because of the risk of vascular collapse.
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Learn More about
Natural Male Enhancements
Viagra is used to treat impotence in men. Viagra increases the body's ability to achieve and maintain an erection during sexual stimulation. Viagra does not protect you from getting sexually transmitted diseases, including HIV. Add Viagra to the list of party drugs connected to unsafe sex. In a survey of San Francisco men seeking public health services for sexually transmitted diseases, 17... 
Provigro, Colossal, Erectol and Vigrolex are medicines from different manufactures that offer remedy to erectile dysfunction. As none of these medicines contain toxic chemical that can be harmful on those who consume it, you can experiment with any of these medicines without fearing about harmful and undisclosed side effects of chemical based medicines.
Effectiveness of a medicine, especially...
Today millions of people all around world are affected by Erectile Dysfunction (ED). Male sexual health gets badly affected by Impotence. Countless relationships suffer because of the inability of male partners to completely satisfy their partners and Impotence is one of the most prominent reason for such an inability. The consequences of a broken relationship are not only suffered by the couple...
Erectile dysfunction which is a very common complaint can be generally rectified by following few simple steps. Here goes the list of simple but effective tips to rectify erectile dysfunction.
Avoid consumption of alcohol. If you are addicted to alcohol restrict the intake. Alcohol acts on central nervous system and causes erectile dysfunction.
Keep away from smoking. Men who smoke suffer...
I have heart disease - are there any erectile dysfunction or
male impotence treatments suitable for me? Heart disease can be
associated with various factors that increase the likelihood of
erectile dysfunction or male impotence, and make treatment more
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Hardening of the arteries (atherosclerosis), which is frequently
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